Rid? no. There are a few "must have" singles that will probably stay in the setlist for a very long time (or if I'll took it more farther - as long as the band active).
Imagine your suggestion: a setlist without the recent hit singles (not talking about how much these songs are good or not, played too much or not - just based on public recognition), which means that What I've Done will be the latest song that most of the crowd knows. The last "super hit" will be from almost a decade ago.
With Hybrid Theory singles there's more room to choose because you've got 4-5 mega hits to choose from, drop Crawling and keep In The End, One Step Closer and Papercut and nobody cares. But with the recent albums, and A Thousand Suns is the best example, they don't have this "pool" of singles/songs to even rotate between.